Entresto must replicate clinical trial results
Missing paperwork reveals antiquated database
Screening recommended for adolescents, but evidence inconclusive for younger children
Application seeks approval for maintenance treatment of adults with schizophrenia
Infection threatens Olympic Games in Rio
The guidelines cover pregnant women and women of reproductive age with possible exposure to the virus
Opioid-related deaths surpass auto fatalities in U.S.
Patients treated with fluoroquinolones and macrolides are most vulnerable

P&T January 2016
Table of Contents


The agreement between Harvard Pilgrim and Amgen on a “pay for performance” deal involving evolocumab could encourage other manufacturers, health plans, and policy-makers to press for value-based pricing as drug costs continue to escalate.
Use of sodium polystyrene sulfonate (SPS) dominates the long-term treatment of hyperkalemia, but two new agents, sodium zirconium cyclosilicate and the recently FDA-approved patiromer, may offer potential advantages compared with SPS.
Coupled with administration support of an action plan that promotes quality of care and a culture of safety, the Medication Error Prioritization System (which automates parts of error review) has led to improvements for an integrated health care system.


Medication Errors
Community liaison programs to cut hospital readmissions
Prescription: Washington
FDA deluged with opinions on biosimilar naming plans.
FDA approvals, drug indications, and updates
Elotuzumab (Empliciti) and ixazomib (Ninlaro) for some multiple myeloma patients; Fluad (influenza vaccine, adjuvanted) for immunization of persons 65 years of age and older; and osimertinib (Tagrisso) for certain non–small-cell lung cancers
Drug Forecast
Alirocumab (Praluent): first in the new class of PCSK9 inhibitors
Pipeline Plus
Analysts foresee substantial growth in the multiple myeloma market in the next decade, driven mainly by the monoclonal antibodies elotuzumab and daratumumab.